Cholera Outbreak



Cuban cholera outbreak reaches Havana 

 The BBC has learned that a patient has been diagnosed with cholera in the Cuban capital, Havana, days after three people died in a rare outbreak in the south-eastern town of Manzanillo.

More than 50 people were infected and about 1,000 have received medical attention.
The authorities say the outbreak is under control but four hospitals are prepared to isolate patients.
They say people became ill after drinking water from contaminated wells.
But it is not clear what the source of the cholera is.
Haiti link
 
Most of the cases were in Cuba's south-eastern Granma province, more than 750km (470 miles) from Havana.

Hundreds of medical professionals from that area, including nurses, have worked and continue to work with patients in Haiti, where tens of thousands of people were infected after a devastating earthquake in 2010.
But the BBC's Sarah Rainsford says that for over a week doctors in Havana have been doing the rounds of their patients, checking for symptoms of cholera.

The infirm, elderly and pregnant have been prioritised.

Now tests on a 60-year-old woman, admitted to hospital on Wednesday, have confirmed that she has the disease.

As she was diagnosed early, doctors say she is in a stable condition.
Health officials said they had "all the necessary resources to provide adequate attention to patients."
They said they had taken a series of measures, including taking samples of water and adding chlorine to purify it, to combat the outbreak.

Cholera is a bacterial infection that can cause severe diarrhoea and dehydration.
The Health Ministry said the last reported cholera outbreak on the island was soon after the 1959 Revolution.



Haiti's cholera row with UN rumbles on


A Haitian teenager receiving treatment for cholera Nearly 500,000 people in Haiti have contracted cholera during the outbreak

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Lawyers representing thousands of cholera victims in Haiti have threatened to take the United Nations to court in the United States, unless the international body responds to a petition for financial compensation.
It is part of a campaign that centres on the extraordinary possibility that the UN - widely seen as a force for good around the world - may have brought cholera into Haiti and as a result may be responsible for nearly 7,000 deaths from the disease.
The UN is being asked to pay $100,000 (£65,000) to the families of those who died and $50,000 (£32,500) to each of the people who fell sick but recovered.
In addition there is a "class action" saying the UN should stop the cholera by rebuilding Haiti's decrepit water and sanitation infrastructure.
If met in total, the claims could cost the international body many billions of dollars.
Cholera is a disease that spreads through human waste and infected water.
Victims can die within hours of the disease taking hold if they don't get treatment. The main symptom is catastrophic dehydration through diarrhoea and vomiting.
'Dire conditions' My journey here began in the pretty mountaintop town of Mirebalais, source of the original infection.
No-one contests that this is the area where the outbreak began last October. But where exactly?
Anti-UN protests in Haiti The cholera outbreak has triggered ongoing protests against the UN in Haiti
The mayor of the town, Lochard Laguerre, has no doubts: "We know that sanitary conditions in the Nepalese UN camp just outside town were dire," he told me.
"They were dumping their sewage near the river and we know that people die from cholera in Nepal. I told the UN commander in the camp about our concerns a week or so before the first outbreak began."
Inside the Mirebalais UN camp, the current officer in charge, Lt Col Tek Chand of the Nepalese army, contested the mayor's account.
"It's impossible. It didn't start here," he said.
Lt Col Tek Chand was not in charge of the camp when the outbreak began - another Nepalese officer was here.
"There has not been a single case of cholera in this camp," he insisted.
In the camp, technicians were monitoring a new, modern sewage treatment plant recently installed by the UN.
At the time of the cholera outbreak, however, the Nepalese had a contract with a Haitian waste-disposal company that was dumping raw sewage into an open pit outside the camp.

“Start Quote

In the court of pubic opinion in Haiti, the UN is already guilty”
Nigel Fisher UN head of Humanitarian Affairs in Haiti.
A report by independent experts commissioned by the UN in New York said sanitary conditions at the camp in Mirebalais were insufficient to prevent the spread of infection into the Artibonite River - Haiti's biggest.
The experts' report also said the strain of cholera that hit Haiti was similar to an Asian strain.
Before this outbreak, the experts said, Haiti had not had cholera for nearly 100 years.
'Fingers pointed' In the capital Port-au-Prince the UN's head of Humanitarian Affairs in Haiti, Nigel Fisher, said the response to the petition was in the hands of lawyers at the UN Secretariat in New York.
But he told me; "I think we all regret the breakout of this thing and I don't think the UN has ever denied the possibility [that it could have been at fault]."
"However I would like to know with some certainty what the source was," he added.
He said that describing it as an "Asian strain" was not helpful.
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"The cholera strain we have in Haiti is the same as the one they have in Latin America and Africa. They all derive from Bangladesh in the 1960s so they are all an Asian strain."
He said every moment he spent trying to establish the exact cause of the outbreak was time he was not spending with his humanitarian team tackling the crisis that was still taking lives.
"Fingers are being pointed", Nigel Fisher accepts, "and in the court of pubic opinion in Haiti, the UN is already guilty".
He was certainly right there. Every single Haitian I met during my two week visit was convinced the UN was responsible.
A protest by about 2,000 people was held outside the UN base in the coastal town of Saint Marc.
"Down with the UN," people shouted and sang, "they brought us cholera."
"I'm here because my father died of cholera," said one of the protesters, Pierre Filsmichel.
"My dad left seven children and a wife. He was the breadwinner of our family, and because of cholera he is now dead. We ask for compensation for all the cholera victims."
There are technical question marks around the culpability of the United Nations in this affair.
Although some scientific experts say the Nepalese base was the source of the cholera, others say they cannot be certain.
UN base in Haiti The UN says it is possible that its forces brought cholera to Haiti, but it is not scientifically proven
A senior UN official, who requested anonymity, pointed out that it was possible for someone to be a cholera carrier without knowing it.
If this had been the case, the UN official said, the source could have been either an unknowing Nepali - or an unknowing Haitian, or anybody else in the country.
Another UN official, who also asked not to be named, said that following a series of internal reports, seen by most senior UN managers, "everyone knew the sanitary situation in the Nepali base was deplorable".
The legal case currently takes the form of a petition under civil law asking the UN to set up a joint UN/Haitian Government commission to hear the cases.
If the civil case is not heard by the joint commission soon, the lawyers say, they will take the matter to court in the United States.
You can hear Mark Doyle's full report Who is responsible for the deadly cholera outbreak in Haiti? by listening to the Assignment programme on the BBC World Service on Thursday 15 December at 09:05 GMT. 


 

Cholera pandemic has a single global source



 How cholera has spread from the Bay of Bengal

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A major cholera pandemic has spread in at least three waves from a single global source: the Bay of Bengal.
A study in Nature reveals cholera's spread over the last 60 years into Asia, Africa, Europe and the Americas, continent-hopping on long-haul flights.
The research by a team from Cambridge's Sanger Institute showed the infection is evolving, with the newest waves showing antibiotic resistance.
A UK expert said it was "a scandal" cholera was still affecting people.
Cholera is a bacterial infection of the intestine that causes diarrhoea. It affects 3-5m people annually in 56 countries, killing between100,000 and 150,000.
If untreated, it can kill within hours through dehydration. It is easily treated by drinking clean water, but without this, severe cases have a 30-50% mortality rate.
'Only explanation' In this study, the researchers sequenced the genome of 154 samples collected from patients around the world. Genome sequencing technologies have been getting better, faster and cheaper. Until recently, sequencing would be carried out on just four or five bacteria samples.
Bay of Benghal The ecology and climate of the Bay of Benghal could be why cholera has spread from there
Similarities between cholera genomes showed how the various strains are related, while subtle differences showed how it is evolving.
By investigating these bacteria at the genetic level, the authors were able to piece together the story of the latest, and ongoing, global cholera pandemic.
"We were surprised to see that the pattern we see is very clear. All of the samples were related. There is a single global source of cholera in the Bay of Bengal," said co-author Dr Nick Thomson of the Sanger Institute.
It is not yet clear why the Bay of Bengal is at the centre of the pandemic, though cholera bacteria exist naturally within some marine ecosystems.
The local ecology, climate, and the presence of large river deltas are likely to be key factors in its presence there.
The results show several cases of cholera suddenly jumping between continents, suggesting that it was spread by passengers on long-haul flights.
"I think that's the only possible explanation. Our data show that this has happened, for example from Angola to South America.
"Many people can have cholera with no symptoms, so they transmit it without realising," added Dr Thomson.
'One fell swoop' The most recent outbreak is in Haiti where it took hold shortly after the 2010 earthquake after being absent for more than a century.
So far it has killed nearly 6,000 people and hospitalised 200,000.

“Start Quote

This is really about poverty”
Dr Valerie Curtis London School of Hygiene & Tropical Medicine
A recent report by the US Centre for Disease Control and Prevention linked this outbreak to the arrival of UN troops from Nepal, a finding supported by this study. In November 2010, the UN issued an appeal for $160m to fight the spread of the cholera in Haiti.
Another worrying pattern emerged from the genome analysis. Three waves of cholera have come out of the Bay of Bengal since the 1950s, and from the second wave onwards, all of the strains were antibiotic resistant.
That means that the resistance was acquired within 15 years of the first clinical use of antibiotics tetracycline and furazolidone for cholera treatment.
Dr Thompson said: "I'm not surprised it happened so fast. We think that antibiotic resistance moves between strains, and in one fell swoop a strain can become multi-resistant."
"Antibiotics are clearly one of the major driving forces in cholera evolution. However, in general antibiotics just reduce the length of infection in people."
Dr Valerie Curtis of the London School of Hygiene & Tropical Medicine said: "It's an appalling scandal that in the 21st century people are still suffering from this ancient disease.
"Cholera is symptomatic of countries where something has gone badly wrong, where the infrastructure of sanitation and clean water has broken down. This is really about poverty.
"What this study shows is that it's easy for pockets of poverty in Africa to affect pockets of poverty in the Americas, for example. It's almost impossible to stop the spread of such diseases but what we must do is invest in the public health of poor countries."



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